2.2.1. Timing Optimization
You can use other options and techniques in the Intel® Quartus® Prime software to meet area and timing requirements. For example, the WYSIWYG Primitive Resynthesis option can perform optimizations on your EDIF netlist in the Intel® Quartus® Prime software.
While simulation and analysis can be performed at various points in the design process, final timing analysis should be performed after placement and routing is complete.