5.1.5. HPS Pin Multiplexing Design Considerations
There is a total of 48 dedicated HPS I/O pins. The HPS component in Platform Designer offers pin multiplexing settings as well as the option to route most of the peripherals into the FPGA fabric.
GUIDELINE: Route the USB, EMAC and Flash interfaces to the HPS Dedicated I/O first, starting with USB.
Intel® recommends that you start by routing high speed interfaces such as USB, Ethernet, and flash to the Dedicated I/O first.