22.214.171.124. Clocking Architecture
Timing failure can occur when the I/O interface at the top of the device connects to logic driven by a regional clock which is in one quadrant of the device, and placement restrictions force long paths to and from I/Os to logic across quadrants.
Use a different type of clock source to drive the logic, such as global, which covers the whole device, or dual-regional which covers half the device. Alternatively, you can reduce the frequency of the I/O interface to accommodate the long path delays. You can also redesign the pinout of the device to place all the specified I/Os adjacent to the regional clock quadrant. This issue can happen when register locations are restricted, such as with Logic Lock regions, clocking resources, or hard blocks (memories, DSPs, IPs).
The Extra Fitter Information tab in the Timing Analyzer timing report informs you when placement is restricted for nodes in a path.