2.4.10. Unused Transceiver Channels
Transceivers in the device degrade over time unless you preserve them. The Intel® Quartus® Prime software generates a warning message if a design contains unused XCVRs.
You do not need to preserve transceivers under 8Gbps. For transceivers over 8Gbps, the best practice is to preserve if there is a possibility for future usage. Otherwise, you can turn the transceivers off. You enable unused transceivers through dynamic reconfiguration or a new device programming file.