Intel® Quartus® Prime Pro Edition User Guide: Design Recommendations
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3.4.5. Increase the Length of Synchronizers to Protect and Optimize
Increase the Synchronizer Chain Length parameter to the maximum length of synchronization chains in your design. If you have synchronization chains longer than 2 identified in your design, you can protect the entire synchronization chain from operations that might reduce MTBF and allow metastability optimizations to improve the MTBF.