DSP Builder for Intel® FPGAs (Advanced Blockset): Handbook
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10.6.4.3. Bit-Accurate Simulation
You can change the global simulation mode via the Control block on the Simulation tab. Refer to the Simulation Mode parameter in the Control block.
You can also change or override the simulation settings locally within a subsystem via the SynthesisInfo block. Refer to the Simulation Mode parameter in the SynthesisInfo block.
DSP Builder offers the following simulation modes that are in increasing order of accuracy: Standard, Bit Accurate, Bit and Cycle Accurate.
Using a higher accuracy simulation mode often ensures that Simulink and RTL simulations match. However, do not use Bit Accurate or Bit and Cycle Accurate simulation with Memory-Mapped library blocks. You should separate bus blocks and those that do nontrivial maths into different subsystems, which allows you to independently set the simulation modes.