The HLGPI[13:0] input only pins of the Cyclone® V SX share pins with the HPS DDR controller. To identify the pin location for these GPI pins, see related solution.
Physically the HLGPI[13:0] signals are connected to GPIO2_porta_input[13:26] in the HPS. You can configure the HLGPI to generate interrupts just like other GPIO in GPIO2 component.
To configure the GPIO interrupts you will configure the following registers - gpio_inten, gpio_intmask, gpio_inttype_level, and the gpio_int_polarity registers. These registers can be found in the address map for the Cyclone V HPS device at the following link:
https://www.intel.com/content/www/us/en/programmable/hps/cyclone-v/hps.html