Does the Intel® Arria® 10 AN708 Application Note PCI Express DMA Reference Design Using External Memory support simulation?

No, the reference design in AN708 Application Note is for hardware functional test only, not for simulation.

You may see one of the following errors:

INFO:          175149 ns  RP LTSSM State: DETECT.ACTIVE                                                                      
FATAL:         175149 ns  LTSSM does not change from DETECT.QUIET                                                            
FAILURE: Simulation stopped due to Fatal error!
FAILURE: Simulation stopped due to error!
$finish called from file "./../..//../../ip/top_tb/top_tb_DUT_pcie_tb/altera_pcie_a10_tbed_161/sim/altpcietb_ltssm_mon.v", line 155.

To run the Intel® Arria® 10  PCI Express simulation, generate the testbench by following the steps provided in Chapter 2 of " Intel® Arria® 10 or Intel® Cyclone® 10 GX Avalon® Memory-Mapped (Avalon-MM) DMA Interface for PCI Express* Solutions User Guide".