Yes. In the EPCQ-A Serial Configuration Device Datasheet (version 2019.10.01) section 1.4.2, a note states that "N.C pins must be left unconnected." This is incorrect. The pins labeled "N.C" are not internally connected, and may be either not connected on the board or connected to ground. Connecting these pins to other signals or voltages has not been characterized or verified, and so is not recommended.
The note in the datasheet is scheduled to be corrected in a future document revision.