No, the SOF file for Intel® Agilex™ devices with R-Tile Transceivers is not compatible between Intel® Quartus® Prime Pro Edition software version 21.1 and version 21.2.
You cannot use a SOF file generated in Intel® Quartus® Prime Pro Edition software version 21.1 in Intel® Quartus® Programmer version 21.2 or to generate any bitstream in Intel® Quartus® Prime Pro Edition software version 21.2 and vice versa.
You will need to regenerate the SOF in Intel® Quartus® Prime Pro Edition software version 21.2 if you want to program using Intel® Quartus® Programmer version 21.2 or to generate any bitstream in Intel® Quartus® Prime Pro Edition software version 21.2.