The PCI Express® HardIP constraints for signals tl_cfg* are ingored in SOPC Builder designs because the altpcierd_tl_cfg_sample module is not used in this mode.
As a result, in pcie_compiler_0.sdc, the SDC constraints that are placed after the comment below will be ignored:
# The following multicycle path constraints are only valid if the logic use to sample the tl_cfg_ctl and tl_cfg_sts signals
Note: These constraints are valid in QSYS and Avalon®-ST HardIP configurations.