Due to the Intel® Arria® 10 external memory interface (EMIF) intellectual property (IP) accessing the MMR registers during the calibration phase, the mmr_readdata_valid signal assertion can be seen from the MMR slave port. This behavior can cause the MMR slave port Avalon® bus to lock up.
Here is a related KDB answer:
https://www.intel.com/content/www/us/en/support/programmable/articles/000085925
This problem is scheduled to be fixed in a future release of the Intel® Quartus® Prime software.