Due to a restriction in the Intel® Quartus® Prime Edition Software, it is not possible to enable the Memory Mapped Configuration and Status Register (MMR) interface in conjunction with the Efficiency Monitor when implementing DDR3 or DDR4 interfaces using the External Memory Interface Intel FPGA IP for Intel® Arria® 10, Intel® Cyclone® 10 GX or Intel® Stratix® 10 devices.
Enabling both options will result in an error like that shown below :
Error: Interface must have an associated clock
There is no planned fix for this restriction.