Yes, there is a known issue with the PFL in the Quartus® II software version 12.1SP1. When data is read from the EPCQ or Micron’s Quad SPI flash device, signal contention between the PFL and the flash device is seen for several pfl_clk clocks at the beginning and end of data being read from the flash device.
A patch is available to fix this problem in the Quartus II software version 12.1SP1. Download and install patch 1.64 from the appropriate link below:
You also need additional timing considerations for flash_io and flash_ncs as shown in the timing diagram.
This is fixed in the Quartus II software version 13.0SP1.