No. For Intel® Stratix® 10 and Intel® Agilex™ devices, in designs which do not include HPS, do not set the HPS/FPGA configuration order as HPS first. Otherwise, you will not be able to access QSPI flash using the Mailbox Client Intel® FPGA IP and you will see error code 0x80 (QSPI_HW_ERROR) for QSPI_SET_CS operation. For details of the operation command and error codes, refer to the Mailbox Client Intel® FPGA IP User Guide.
This problem is fixed starting with the Intel® Quartus® Prime Pro/Standard Edition Software version 22.1.