No, as long as the transceiver channels are not kept in analog reset.
Device Family: Intel® Stratix® 10 GX, Intel® Stratix® 10 MX, Intel® Stratix® 10 SX, Intel® Stratix® 10 TX
Intel Software: Quartus Prime Pro
Type: Errata
Area: HSIO
Last Modified: October 15, 2019
Version Found: v19.3
Bug ID: 14010227986