Due to a known problem in Intel® Quartus® Prime Pro Edition software version 20.2 and later, ASx4 configuration of Intel® Stratix® 10 devices may fail intermittently when the below clocking combinations are used.
AS_CLK is 100MHz and OSC_CLK_1 is 125MHz
AS_CLK is 125Mhz and OSC_CLK_1 is 25MHz
AS_CLK is 133MHz and OSC_CLK_1 is 25MHz
All other combinations are not impacted.