You may see an incorrect frequency or behavior during the simulation of cascaded IOPLL IP for Intel® Arria® 10, Intel Cyclone® 10 GX, and Intel® Stratix® 10 devices.
This is due to a bug in the simple simulation model generated from the IOPLL IP by default.
To work around this, enable the PLL Auto Reset option in Physical PLL Settings before IOPLL IP generation. This enables the advanced simulation model, which is not impacted by this issue.
This problem was fixed in Intel® Quartus® Prime Software version 22.1