White Paper: The speed of DNA sequencing has increased considerably with the introduction of next-generation sequencing platforms. Modern systems can generate several hundred gigabytes of raw sequence data to be processed, which can quickly become a computational bottleneck. To overcome this bottleneck, Halvade*, a modular framework that enables sequencing pipelines to be executed in parallel on a... multi-node or multi-core compute infrastructure, was developed. Halvade is able to strongly reduce the runtime for post-sequencing analysis. A key feature of Halvade is that it achieves very high parallel efficiency which means that computational resources are efficiently used to reduce runtime.